Golden Globe Awards

2008: Best Performance by an Actress in a Mini-Series or a Motion Picture Made for Television – The Starter Wife (Nominated)
2005: Best Actress in a Television Series: Musical or Comedy – Will & Grace (nominated)
2004: Best Actress in a Television Series: Musical or Comedy – Will & Grace (nominated)
2003: Best Actress in a Television Series: Musical or Comedy – Will & Grace (nominated)
2002: Best Actress in a Television Series: Musical or Comedy – Will & Grace (nominated)
2001: Best Actress in a Television Series: Musical or Comedy – Will & Grace (nominated)
2000: Best Actress in a Television Series: Musical or Comedy – Will & Grace (nominated)

Emmy Awards

2007: Outstanding Lead Actress in a Miniseries or Movie – The Starter Wife (Nominated)
2006: Outstanding Lead Actress in a Comedy Series – Will & Grace (Nominated)
2003: Outstanding Lead Actress in a Comedy Series – Will & Grace (Won)
2002: Outstanding Lead Actress in a Comedy Series – Will & Grace (Nominated)
2001: Outstanding Lead Actress in a Comedy Series – Will & Grace (Nominated)
2000: Outstanding Lead Actress in a Comedy Series – Will & Grace (Nominated)

Screen Actors Guild Awards

2008: Outstanding Performance by a Female Actor in a Television Movie or Miniseries – The Starter Wife (Nominated)
2005: Outstanding Performance by an Ensemble in a Comedy Series – Will & Grace (Nominated)
2004: Outstanding Performance by an Actress in a Comedy Series – Will & Grace (Nominated)
2003: Outstanding Performance by an Ensemble in a Comedy Series – Will & Grace (Nominated)
2002: Outstanding Performance by an Ensemble in a Comedy Series – Will & Grace (Nominated)
2001: Outstanding Performance by a Female Actor in a Comedy Series – Will & Grace (Nominated)
2001: Outstanding Performance by an Ensemble in a Comedy Series – Will & Grace (Nominated)

Teen Choice Awards

2006: Choice TV Actress: Comedy – Will & Grace (nominated)
2002: Choice TV Actress: Comedy – Will & Grace (nominated)
2001: Choice TV Actress: Comedy – Will & Grace (nominated)

Gracie Allen Awards

2008: Outstanding Female Lead – Mini-Series – The Starter Wife (Won )

People’s Choice Award

2005: Favorite Female Television Star (Nominated)
2005: Favorite Funny Female Star (Nominated)

Satellite Awards

2007: Best Actress in a Miniseries or a Motion Picture Made for Television – The Starter Wife (Nominated)
2004: Best Performance by an Actress in a Series, Comedy or Musical – Will & Grace (Nominated)
2003: Best Performance by an Actress in a Series, Comedy or Musical – Will & Grace (Won)
2002: Best Performance by an Actress in a Series, Comedy or Musical – Will & Grace (Won)

TV Guide Awards

2001: Actress of the Year in a Comedy Series – Will & Grace (Won )

Viewers for Quality Television Awards

2000: Best Actress in a Quality Comedy Series – Will & Grace (Nominated)

Women in Film Lucy Awards

2005: Lucy Award (Won)